Senior researchers at the Institute Stewarz to explore whether the immune system is doing by inhibiting the ability of worms infected Almistorqat infected regenerative. Where they discovered that when the inhibition of gene activated kinase 1 transforming growth factor beta (TAK1 kinase) when the worms, they become capable of healing.
Discover by chance
Transformation which began a surprise Kmadilh in the lab, to the discovery of how to promote the renewal of organisms even in the case of an infection.
The Almistorqat small flat worms that can resist bacteria highly pathogenic to man, also owns an amazing regenerative abilities.
The researchers at the Institute Stewarz basin fill these small worms flat, but the infection hit part of Almistorqat rally, which led to the injury of some lesions around the eyes, and increased in size to the head of worms degradation. It is worth mentioning that in normal circumstances, simply grows a new head of worms, but it seems the infection prevented them from regeneration, the researchers tried to move the sound worms to another basin, but she got sick quickly once removed from that exact environment healthy.
Image rights: Steve Begin, Flickr
Activated kinase 1 transforming growth factor beta (TAK1 kinase)
After knowing that the worms hit by pests had a huge rush of Proteus bacteria (which can also cause peptic ulcers and stomach cancer in humans), the d. Chris Arnold - who had recently begun conducting post-doctoral research at the time of this study - and his colleagues tested whether the immune system inhibited the ability of germs to regenerate, researchers based on this hypothesis by using RNA interference to disrupt the natural immune system. Through Stop activated kinase 1 transforming growth factor beta (TAK1 kinase), became effective regenerative capacity of worms again.
Author prominent Alejandro Sanchez Alvarado described the operation as "confused," and that it is completely different from the initial hypothesis, which set off to prove, he said: "We believe that this track has been working to get rid of the infected cells, and thus removed so that the infection can not spread to the tissues sound. when we inhibit this path only, we allow that to happen regeneration even in the event of a contagion. "
The researchers hope to conduct more experiments and testing to explore how to apply these results to the possibilities of human beings, to deal with some cases such as chronic wounds and non-curable.